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Ritonavir or lopinavir/ritonavir significantly improve plasma concentrations of oxycodone in nutritious human volunteers resulting from inhibition of CYP3A4 and CYP2D6.[fifty eight] Rifampicin considerably lessens plasma concentrations of oxycodone as a consequence of sturdy induction of CYP3A4.Opioid withdrawal commonly lasts a few months, but it